Restless legs syndrome (RLS) is a common disorder affecting up to 10-15% of the population older than 65 years, with an over-representation among women. Individuals with RLS suffer from uncomfortable sensations in their legs (but may also involved other body parts), typically at night when they are trying to fall asleep. As a result, sleep initiation is disturbed, and these patients quality of life is therefore affected. Furthermore, these patients are at increased risk for cardiovascular diseases, depression and other conditions.
Large scale GWASs (in which we are involved) suggest that genetics has an important role in RLS, and there are numerous genes potentially involved in its etiology. Our research is focus on identifying these genes, genetic interactions and modifiers affecting RLS, and potential drug targets.